Threadsy is an integrated communication client combining email, Facebook, Twitter and your social networks into an unified experience with contextual information on people and their latest adventures on the interwebs. Threadsy even lets you archive, reply, delete and otherwise control your web life from one big page.
OtherInbox is the cure for email overload -- it provides consumers with a free email account that automatically organizes newsletters, social networking updates, coupons and receipts from online purchases so that its easy to find the most interesting things and ignore the rest.